Emily Preston

Few characters make their Marvel debut alongside the Merc with a Mouth himself, but Emily Preston stepped onto the scene in 2013's Deadpool #1 — courtesy of creator Tony Moore — and has kept remarkable company ever since, sharing pages with Wade Wilson, Captain America, and Doctor Strange across a Modern Age run stretching over a decade. Her appearances span some of Deadpool's most celebrated volumes, including Deadpool: World's Greatest, marking her as a recurring presence in the chaotic corner of the Marvel Universe that orbits everyone's favorite fourth-wall-breaker. She may not rack up the highest appearance count, but any character woven into Deadpool's world from the very first issue of that 2013 launch carries a special significance for collectors who know their runs.