Lady Octopus

Slithering out of the Modern Age with a Brian Michael Bendis and Gabriele Dell'Otto debut in Secret War (2006), Lady Octopus is a Marvel villain who has carved out a genuinely menacing corner of Spider-Man's world. Over roughly two decades she's tangled with the likes of Spider-Man, Electro, and Francine Frye across titles like The Amazing Spider-Man, Sinister War, and Spider-Society — serious company that speaks to her staying power in Marvel's rogues' gallery. With 33 catalog appearances and a key issue to her name, she's no footnote — she's a recurring threat whose presence signals that the stakes just got considerably higher.