Miss Itch

A deliciously named villain who slithered into the Marvel Universe in 2000, Miss Itch made her debut in Spider-Woman #13, courtesy of creator Chris Giarrusso, arriving in the thick of the Modern Age with mischief clearly on her agenda. Her handful of appearances keep her in striking company — sharing pages with Spider-Woman herself, Mattie Franklin, and the memorably named Mr. Scratch and Flesh — a rogues' gallery that signals she belongs to a genuinely wild corner of Marvel's web. With only five catalog appearances, she's the kind of rare, blink-and-you'll-miss-her figure that makes dedicated Spider-Woman readers feel like they're in on a secret, and that name alone is enough to make any collector do a double-take.