Typhoid Mary
Few villains to emerge from the Copper Age have burned as brightly — or as unpredictably — as Typhoid Mary, unleashed on Marvel readers in Daredevil #254 in 1988 by the electric creative team of Ann Nocenti and John Romita Jr. Born into a world where Daredevil, the Kingpin, and Spider-Man prowl the same shadowy streets, she carved out a reputation dangerous enough to earn a key-issue debut and sustain nearly four decades of appearances across Daredevil, Marvel Comics Presents, and Captain America. That kind of longevity — 105 appearances and counting, stretching from 1988 all the way to 2026 — speaks to a character who genuinely unsettles the Marvel universe in ways that keep writers coming back. If you haven't spent time with Typhoid Mary, you're missing one of the most compelling and enduring figures the Copper Age gave us.
#254
Trivia
- 🗓️ Typhoid Mary first appeared in Daredevil #254 in 1988 — that's 38 years ago. It's a recognized key issue.
- 🎨 Co-created by Ann Nocenti and John Romita Jr..
- 🏆 Ranks #1,399 of 59,192 characters in our catalog by number of appearances — one of the most-published characters we track.
- 📚 Appears in 105 issues across 57 different series.
- ⭐ 1 of their appearances are key issues collectors actively chase.
- 📈 Has appeared in comics for 38 years (1988–2026) — a true Copper/Modern Age mainstay.