The Amazing Spider-Man #522
In "Moving Targets," Spider-Man returns to confront a man he once saved—only to discover the man is now Hydra’s leader. With a hidden underground base beneath the man’s home and a Hydra costume in hand, Spider-Man infiltrates the facility, uncovering a plan to poison a vital Midwest water supply. As he races to warn the Avengers, he’s met with a chilling obstacle: Hydra’s own squad of super-powered Avengers look-alikes. Written by J. Michael Straczynski and illustrated by Mike Deodato, with inks by Joe Pimentel and Tom Palmer, colors by Matt Milla, and letters by VC's Cory Petit, this 2005 issue features a cover by Kaare Andrews.
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Spider-Man returns to investigate a man he saved from Hydra who just happens to be the current leader of the organization. He discovers a vast underground complex under the man's house and dons a Hydra costume to infiltrate the base. Spider-Man learns that Hydra is planning on polluting an important Midwest water supply and takes off to warn his fellow Avengers. Unfortunately, Hydra's own super powered Avengers look alikes stand in his way.
Plot details indexed by the Grand Comics Database (CC BY-SA).