John F. Kennedy

Few real-world figures have left as distinctive a mark on Silver Age comics as John F. Kennedy, who first appeared in Mad #60 in 1961 — brought to the page by the legendary Antonio Prohías — and has since turned up across 45 catalog appearances spanning an remarkable 64 years. His comic book presence is a fascinating slice of American cultural history, popping up most frequently in the satirical pages of Mad and Sick, where he keeps extraordinary company alongside the likes of Richard Nixon, Alfred E. Neuman, Ronald Reagan, Harry S. Truman, and Lyndon Johnson. With two key-issue appearances to his name and a footprint stretching all the way to 2025, Kennedy stands as one of the most enduring real-world presences in comics — a reminder of just how deeply the medium has always engaged with the world beyond its panels.